In Tennessee:

• From the east (and I-81): take I-40 to Exit 407 (Sevierville) to TN Route 66 South, and continue to U.S. 441 South. Follow U.S. 441 to Park.
• From I-40 in Knoxville: exit 386B U.S. Highway 129 South to Alcoa/Maryville. At Maryville proceed on U.S. 321 North through Townsend. Continue on TN Highway 73 to the Park.

In North Carolina:

• From I-40, take U.S. Route 19 West through Maggie Valley. Proceed to U.S. 441 North at Cherokee. Follow 441 N into the Park.
• From Atlanta and points south: follow U.S. 441 and 23 North. U.S. 441 North leads to the Park.

The nearest major airport in Tennessee is McGhee-Tyson (TYS) in Alcoa, 45 miles west of Gatlinburg. North Carolina's, Asheville Airport is 60 miles east of Cherokee. There is no train or bus service.